The effects of ileo-jejunal transposition (IJT) on intestinal structure, gastrointestinal hormones and D-glucose- and L-glycine-evoked potential difference (PD) have been studied in dogs. IJT was performed by isoperistaltic interposition of the distal fourth of the small bowel in the jejunum, 15 cm distal from the ligament of Treitz. Following IJT hyperenteroglucagonemia and an increase in mucosal thickness of the whole small intestine were observed. This suggested the possibility that enteroglucagon stimulates intestinal mucosal growth as a circulating hormone. The D-glucose-evoked PD in the mucosa of the transposed ileum was much lower than in the preoperative ileal mucosa and resembled that of the normal jejunum. On the other hand, L-glycine-evoked PD showed no difference before and after IJT. These results suggest that enteroglucagon may play an important role in the intestinal adaptation mechanisms and that functional adaptation of intestinal mucosa may occur after IJT.
|出版物ステータス||Published - 1988 1 1|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)