Effect of Fat Loading Test on Alteration of Plasma Lipids and Gastrointestinal Hormones in Dog with Ileo-jejunal Transposition

Morihiko Toda, Iwao Sasaki, Hiroo Naito, Yuji Funayama, Yasuhiko Kamiyama, Michinaga Takahashi, Kohei Fukushima, Seiki Matsuno

研究成果: Article査読

抄録

Experimental studies were carried out to investigate the effect of ileo-jejunal transposition (UT) upon the plasma lipids and gastrointestinal hormones after the oral administration of butter (2g/kg). Dogs undergoing either UT (n=6) or sham operation (n=5) were compared and the following results were obtained. 1) In both the UT and the sham groups the plasma triglyceride levels at 0 to 30 minutes after the ingestion of butter significantly increased after the operation. The plasma free fatty acid and cholesterol levels showed no differences afte surgery. 2) Five weeks after UT, a significant increase in the fasting plasma total glucagon-like immunoreactivity (total-GLI) level was observed, but the postprandial plasma total-GLI level showed no difference after IJT. 3) The plasma gastric inhibitory polypeptde response to butter ingestion was lower after IJT. The plasma gastrin and insulin levels showed no differences after IJT. The present studies suggest that the absorption of fat is not found to be affected by IJT. Digestion of intraluminal fats may play an important role in the release of enteroglucagon.

本文言語English
ページ(範囲)867-874
ページ数8
ジャーナルThe Japanese Journal Of Gastroenterological Surgery
23
4
DOI
出版ステータスPublished - 1990 2月 1

ASJC Scopus subject areas

  • 外科
  • 消化器病学

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