Effect of dietary n-3 polyunsaturated fatty acids on cholesterol synthesis and degradation in rats of different ages

Young Soon Choi, Shoichiro Goto, Ikuo Ikeda, Michihiro Sugano

研究成果: Article査読

73 被引用数 (Scopus)

抄録

Male Sprague-Dawley rats four weeks or eight months of age were fed purified diets containing 10% fat, either as a blend of safflower oil and palm olein (polyunsaturated fatty acids, PUFA, 34%), a blend of linseed oil and palm olein (PUFA, 33%) or sardine oil (PUFA, 33%) for four weeks. In other trials, sterol contents were made equivalent by supplementing cholesterol to a blend of corn oil and palm olein (PUFA, 30%) or phytosterol to sardine oil (PUFA, 30%). Fish oil was hypolipidemic in rats of different ages, but it tended to increase liver cholesterol in adult animals and this was not improved by the addition of phytosterol. The age-dependent increase in liver cholesterol was not duplicated in rats fed a vegetable fat blend supplemented with cholesterol. At both ages, liver 3-hydroxy-3-methylglutaryl coenzyme A reductase activity was lower in the sardine oil than in the other groups. There were no significant age- or diet-related differences in the activity of liver cholesterol 7α-hydroxylase. Fecal steroid excretion was comparable in age-matched rats fed diets supplemented either with cholesterol or phystosterol. Sardine oil reduced the Δ6-desaturase activity markedly as compared with linseed oil, and age-dependent reduction of the desaturase activity was observed in all dietary groups examined. Thus, the results showed a specific effect of fish oil on lipid metabolism.

本文言語English
ページ(範囲)45-50
ページ数6
ジャーナルLipids
24
1
DOI
出版ステータスPublished - 1989 1月 1
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 有機化学
  • 細胞生物学

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