The regulatory role of the presence of pancreatic juice in the intestinal lumen on gut hormone release is still unclear, especially in dogs. This study was designed to elucidate the effect of chronic absence of pancreatic juice in the upper intestinal lumen on gut hormone release and subsequent changes of intestinal structure using chronic pancreatic juice diversion model. Models were prepared in mongrel dogs. Isolated duodenal pouch containing pancreatic papilla was transferred to the middle part of the ileum without bile duct ligation. In this model, pancreatic juice was diverted from the proximal three-fourth of the small intestine with normal bile flow. Oral butter loading tests were carried out before and after these procedures. Plasma concentration of gut hormones (total-GLI, GIP) were measured. Morphological changes of the small intestine were evaluated microscopically. After pancreatic juice diversion, (1)Butter-stimulated release of GIP were significantly lower than the control. (2)release of total-GLI were significantly greater than the control. (3)the mucosal thickness along the whole small intestine was significantly increased. These results suggested that chronic absence of pancreatic juice in the intestinal lumen causes growth of the intestinal mucosa and these changes may be mediated by gut-GLI.
|出版ステータス||Published - 1995 1月 1|
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