抄録
We carried out an experimental study to evaluate the effect of basic fibroblast growth factor (bFGF)-containing collagen gel on vascularization in esophageal tissue engineering. We compared an acellular collagen sponge scaffold and an acellular collagen gel scaffold in combination with bFGF using a canine model. The construct was implanted in the cervical esophagus and the regenerated tissue was evaluated one month after surgery. Histological analysis confirmed a significantly large amount of blood vessels in the bFGF-containing collagen gel group as compared to the collagen gel group without bFGF (bFGF (-)). However, in the collagen sponge groups, no difference was observed between the bFGF (+) group and the bFGF (-) group. These results showed that bFGF-containing collagen gel is suitable not only for an acellular scaffold for tissue engineering but also for an effective tropic factor vehicle in vivo.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 241-244 |
| ページ数 | 4 |
| ジャーナル | International Journal of Artificial Organs |
| 巻 | 26 |
| 号 | 3 |
| DOI | |
| 出版ステータス | Published - 2003 3月 1 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 医学（その他）
- バイオエンジニアリング
- 生体材料
- 生体医工学