Effect of basic fibroblast growth factor on vascularization in esophagus tissue engineering

Yashio Hori, T. Nakamura, D. Kimura, K. Kaino, Y. Kurokawa, S. Satomi, Y. Shimizu

研究成果: Article査読

21 被引用数 (Scopus)

抄録

We carried out an experimental study to evaluate the effect of basic fibroblast growth factor (bFGF)-containing collagen gel on vascularization in esophageal tissue engineering. We compared an acellular collagen sponge scaffold and an acellular collagen gel scaffold in combination with bFGF using a canine model. The construct was implanted in the cervical esophagus and the regenerated tissue was evaluated one month after surgery. Histological analysis confirmed a significantly large amount of blood vessels in the bFGF-containing collagen gel group as compared to the collagen gel group without bFGF (bFGF (-)). However, in the collagen sponge groups, no difference was observed between the bFGF (+) group and the bFGF (-) group. These results showed that bFGF-containing collagen gel is suitable not only for an acellular scaffold for tissue engineering but also for an effective tropic factor vehicle in vivo.

本文言語English
ページ(範囲)241-244
ページ数4
ジャーナルInternational Journal of Artificial Organs
26
3
DOI
出版ステータスPublished - 2003 3 1

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 医学(その他)
  • 生体材料
  • 生体医工学

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