Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines

Risa Takeuchi, Hiroshi Hoshijima, Noriko Onuki, Hiroshi Nagasaka, Shahead Ali Chowdhury, Masami Kawase, Hiroshi Sakagami

研究成果: Article

12 引用 (Scopus)

抜粋

The possible apoptosis-inducing activity of codeinone, an oxidative metabolite of codeine, without or with anticancer drugs, was investigated. Codeinone induced internucleosomal DNA fragmentation in human promyelocytic leukemia cells (HL-60), but not in human squamous cell carcinoma cells (HSC-2). Codeinone dose-dependently activated caspase-3 in both of these cells, but to a much lesser extent than that attained by actinomycin D. This property of codeinone was similar to what we have found previously in α,β- unsaturated ketones. Codeinone did not activate caspase-8 or caspase-9 in these cells. The cytotoxic activity of codeinone against HSC-2 cells was inhibited by N-acetyl-L-cysteine, but somewhat additively stimulated by sodium ascorbate, epigallocatechin gallate, hydrogen peroxide, sodium fluoride, 5-fluorouridine, cisplatin, doxorubicin and methotrexate. These data suggest that codeinone has possible antitumor potential, in addition to its action as a narcotic analgesic, even though it induces incomplete apoptosis-associated characteristics.

元の言語English
ページ(範囲)4037-4041
ページ数5
ジャーナルAnticancer research
25
発行部数6 B
出版物ステータスPublished - 2005 11 1
外部発表Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • これを引用

    Takeuchi, R., Hoshijima, H., Onuki, N., Nagasaka, H., Chowdhury, S. A., Kawase, M., & Sakagami, H. (2005). Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines. Anticancer research, 25(6 B), 4037-4041.