Efavirenz-induced neurological symptoms in rare homozygote CYP2B6 *2/*2 (C64T)

Osamu Usami, Yugo Ashino, Yuichi Komaki, Masafumi Tomaki, Toshiya Irokawa, Tsutomu Tamada, Tsunefusa Hayashida, Katsuji Teruya, Toshio Hattori

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Some of the HIV-1-infected patients who were given highly active anti-retroviral therapy (HAART) including efavirenz (EFV) presented adverse central nervous system (CNS) symptoms such as fatigue and insomnia. The incidence of adverse CNS symptoms is associated with hepatic cytochrome P450 isozymes (CYP2B6) polymorphisms. For example, CYP2B6 *6 (G516T and A785G) and *7 (G516T, A785G and C1459T) prolonged the EFV half-life despite discontinuation of EFV. CYP2B6 *2/*2 (C64T) is extremely rare and there have been no data describing the EFV plasma concentrations in C64T homozygous patients, who developed adverse CNS symptoms. C64T homozygous possibly has some catalytic defects.

本文言語English
ページ(範囲)575-576
ページ数2
ジャーナルInternational Journal of STD and AIDS
18
8
DOI
出版ステータスPublished - 2007 8月 1

ASJC Scopus subject areas

  • 皮膚病学
  • 公衆衛生学、環境および労働衛生
  • 感染症
  • 薬理学(医学)

フィンガープリント

「Efavirenz-induced neurological symptoms in rare homozygote CYP2B6 *2/*2 (C64T)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル