Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations

N. Sasano, A. Enomoto, Y. Hosoi, Y. Katsumura, Y. Matsumoto, A. Morita, K. Shiraishi, K. Miyagawa, H. Igaki, K. Nakagawa

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Edaravone has been reported to have a radioprotective effect at high concentrations. We now report that a lower dose of edaravone enhanced X-ray-induced apoptosis of some cell lines harboring p53 wild-type status, such as MOLT-4, Nalm-6, and HepG2. The knock-down of p53 using siRNA in MOLT-4 cells abolished the radiosensitizing effect of edaravone. Enhanced phosphorylations of p53 at Ser 15 and Ser 20 and up-regulation of PUMA, a p53 target protein, were observed after X-irradiation in the presence of edaravone. We conclude that the low dose of edaravone sensitized cells to X-irradiation by promoting the p53-dependent apoptotic signaling pathway.

本文言語English
ページ(範囲)52-57
ページ数6
ジャーナルCancer Letters
293
1
DOI
出版ステータスPublished - 2010 7
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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