TY - JOUR
T1 - Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers
AU - Yamagishi, Hatsushi
AU - Koike, Tomoyuki
AU - Ohara, Shuichi
AU - Horii, Toru
AU - Kikuchi, Ryousuke
AU - Kobayashi, Shigeyuki
AU - Abe, Yasuhiko
AU - Iijima, Katsunori
AU - Imatani, Akira
AU - Suzuki, Kaori
AU - Hishinuma, Takanori
AU - Goto, Junichi
AU - Shimosegawa, Tooru
PY - 2008/4/7
Y1 - 2008/4/7
N2 - Aim: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. Methods: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was performed on the day of treatment. Blood samples were also collected after the administration of each drug. Results: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. Conclusion: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.
AB - Aim: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. Methods: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was performed on the day of treatment. Blood samples were also collected after the administration of each drug. Results: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. Conclusion: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.
KW - Blood drug concentration
KW - Cytochrome P450 2C19 extensive metabolizers
KW - H pylori-negative
KW - Intragastric pH
KW - LPZ 30 mg orally disintegrating tablets
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U2 - 10.3748/wjg.14.2049
DO - 10.3748/wjg.14.2049
M3 - Article
C2 - 18395905
AN - SCOPUS:44849126313
VL - 14
SP - 2049
EP - 2054
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 13
ER -