Early appearance and activation of natural killer cells in tumor‐infiltrating lymphoid cells during tumor development

Shin Kurosawa, Goro Matsuzaki, Mamoru Harada, Takashi Ando, Kikuo Nomoto

    研究成果: Article査読

    31 被引用数 (Scopus)

    抄録

    We investigated NK cell infiltration into tumor developing lesions at early stage of tumor development after intraperitoneal inoculation of 3LL lung carcinoma into syngeneic C57BL/6 mice. Natural killer (NK) cells, which were detected by anti‐NK 1.1 monoclonal antibody (mAb), remarkably increased in number in tumor‐developing lesions (peritoneal cavity) as early as day 3 after inoculation of 3LL. The tumor‐infiltrating NK cells from 3LL‐inoculated mice produced a high level of interferon‐γ by co‐culture with 3LL and showed enhanced cytotoxic activities against both NK‐sensitive (YAC‐1) and NK‐resistant (3LL and P815) tumors. Furthermore, mice depleted of NK cells by injection of anti‐NK 1.1 mAb or antiasialo GM1 antibody showed shorter survival times after intraperitoneal inoculation of 3LL when compared with control mice. These results suggest that NK cells infiltrate the tumor‐developing lesion at an early stage and may participate in the early protection against tumors through production of a high amount of interferon‐γ and enhanced cytotoxicity at tumor‐bearing sites.

    本文言語English
    ページ(範囲)1029-1033
    ページ数5
    ジャーナルEuropean Journal of Immunology
    23
    5
    DOI
    出版ステータスPublished - 1993 5月

    ASJC Scopus subject areas

    • 免疫アレルギー学
    • 免疫学

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