DzMab-1: Anti-Human Diacylglycerol Kinaseζ Monoclonal Antibody for Immunocytochemistry

Tomoyuki Nakano, Satoshi Ogasawara, Toshiaki Tanaka, Yasukazu Hozumi, Masato Sano, Yusuke Sayama, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Kaoru Goto

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol (DG) to phosphatidic acid (PA). As both DG and PA serve as lipidic second messengers, DGK plays a pivotal role in controlling the balance of two signaling pathways mediated by DG and PA in cellular functions. DGKζ, one member of the mammalian DGK family, is reported to contain a nuclear localization signal, which suggests its functional role in the nucleus. Previously, morphological studies using tagged expression vectors and immunostaining of rat tissues or cells have revealed that DGKζ localizes mainly to the nucleus. However, a limited number of studies reported the detailed localization of native protein of DGKζ in human tissues and cells. In this study, we developed a novel anti-human DGKζ monoclonal antibody, DzMab-1, which is very advantageous in immunocytochemistry of human cultured cells.

本文言語English
ページ(範囲)179-182
ページ数4
ジャーナルMonoclonal antibodies in immunodiagnosis and immunotherapy
38
4
DOI
出版ステータスPublished - 2019 8

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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