Dynein-Mediated Regional Cell Division Reorientation Shapes a Tailbud Embryo

研究成果: Article査読

抄録

Regulation of cell division orientation controls the spatial distribution of cells during development and is essential for one-directional tissue transformation, such as elongation. However, little is known about whether it plays a role in other types of tissue morphogenesis. Using an ascidian Halocynthia roretzi, we found that differently oriented cell divisions in the epidermis of the future trunk (anterior) and tail (posterior) regions create an hourglass-like epithelial bending between the two regions to shape the tailbud embryo. Our results show that posterior epidermal cells are polarized with dynein protein anteriorly localized, undergo dynein-dependent spindle rotation, and divide along the anteroposterior axis. This cell division facilitates constriction around the embryo's circumference only in the posterior region and epithelial bending formation. Our findings, therefore, provide an important insight into the role of oriented cell division in tissue morphogenesis.

本文言語English
論文番号100964
ジャーナルiScience
23
3
DOI
出版ステータスPublished - 2020 3 27

ASJC Scopus subject areas

  • General

フィンガープリント 「Dynein-Mediated Regional Cell Division Reorientation Shapes a Tailbud Embryo」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル