Dynamic protein palmitoylation in cellular signaling

Tsuyoshi Iwanaga, Ryouhei Tsutsumi, Jun Noritake, Yuko Fukata, Masaki Fukata

研究成果: Review article査読

82 被引用数 (Scopus)

抄録

Protein S-palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating protein trafficking and function. The unique reversibility of protein palmitoylation allows proteins to rapidly shuttle between intracellular membrane compartments. Importantly, this palmitate cycling can be regulated by some physiological stimuli, contributing to cellular homeostasis and plasticity. Although the enzyme responsible for protein palmitoylation had been long elusive, DHHC family proteins, conserved from plants to mammals, have recently emerged as palmitoyl acyl transferases. Integrated approaches including advanced proteomics, live-cell imaging, and molecular genetics are beginning to clarify the molecular machinery for palmitoylation reaction in diverse aspects of cellular functions.

本文言語English
ページ(範囲)117-127
ページ数11
ジャーナルProgress in Lipid Research
48
3-4
DOI
出版ステータスPublished - 2009 5
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 細胞生物学

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