Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation: Report of 2 cases

Yui Mano, Toshihiro Kumabe, Ichiyo Shibahara, Ryuta Saito, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Dysembryoplastic neuroepithelial tumors (DNETs) have conventionally been regarded as benign and stable tumors and considered curable with surgery without adjunctive therapy. Recently, recurrent DNETs with or without malignant transformation have been described. The authors report 2 unusual cases of DNET: 1) an enlarging lesion that developed an enhancing component over the natural course of 4 years, and 2) a recurrent DNET that developed an enhancing component 10-11 years after gross-total resection. The patient in the first case was treated with subtotal resection and adjuvant radiochemotherapy; histological examination of the tumor led to the diagnosis of DNET, WHO Grade I, for the nonenhancing component and anaplastic oligodendroglioma, WHO Grade III, for the enhancing component. The patient in the second case was treated with repeat gross-total resection; the original tumor had been histologically diagnosed as DNET, and the nonenhancing and enhancing components of the recurrent tumor were diagnosed as simple and complex forms of DNET, respectively. These and previous reports suggest an aggressive subtype of DNETs. If follow-up MRI reveals progressive behavior, resection should be performed without delay. Additional radiochemotherapy is needed if the histological diagnosis demonstrates malignant transformation.

本文言語English
ページ(範囲)518-525
ページ数8
ジャーナルJournal of Neurosurgery: Pediatrics
11
5
DOI
出版ステータスPublished - 2013 5

ASJC Scopus subject areas

  • 外科
  • 小児科学、周産期医学および子どもの健康
  • 臨床神経学

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