Dual role of NF-κB in apoptosis of THP-1 cells during treatment with etoposide and lipopolysaccharide

Keiko Sato, Takahiro Taniguchi, Maiko Suzuki, Fumiaki Shinohara, Haruhiko Takada, Hidemi Rikiishi

研究成果: Article査読

8 被引用数 (Scopus)

抄録

One of the mechanisms repressing apoptosis in tumor cells can involve the expression of anti-apoptotic NF-κB target genes. In this study, we demonstrated that a potent NF-κB inhibitor, Nα-tosyl-L-lysinyl chloromethyl ketone (TLCK), inhibits apoptosis of THP-1 cells triggered by etoposide (VP16), and actinomycin D (ACT D) or cycloheximide inhibits apoptosis. However, persistent activation of NF-κB by lipopolysaccharide (LPS) led to the survival of leukemic cells against VP16-induced apoptosis. Thus, the molecular events (Bax/X-chromosome-linked IAP (XIAP)) occurring downstream of NF-κB activation during VP16 and/or LPS stimulation may become important to understand the multiple effects of NF-κB.

本文言語English
ページ(範囲)63-69
ページ数7
ジャーナルLeukemia Research
28
1
DOI
出版ステータスPublished - 2004 1
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 腫瘍学
  • 癌研究

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