Dual effects of the substrate and pterins on the kinetics of CO binding to neuronal nitric oxide synthase: A laser flash photolysis study

Simona N. Bengea, Yasuyuki Araki, Osamu Ito, Jotaro Igarashi, Hirofumi Kurokawa, Toru Shimizu

研究成果: Article査読

抄録

Derivatives of pterin, an important cofactor for neuronal nitric oxide synthase, markedly changed the kinetics of CO binding to the enzyme-bound heme. In the absence of the substrate, L-Arg, CO binding was dependent on the CO concentration for pterin complexes, whereas in the presence of L-Arg, it became CO-independent for most pterin complexes. This suggests dual effects of substrate and pterin binding on the kinetics and access of CO to the ligand channel.

本文言語English
ページ(範囲)752-753
ページ数2
ジャーナルChemistry Letters
34
6
DOI
出版ステータスPublished - 2005 6 5

ASJC Scopus subject areas

  • 化学 (全般)

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