Dopamine D1 receptor antagonist inhibits swallowing reflex in guinea pigs

Yu Xia Jia, Kiyohisa Sekizawa, Takashi Ohrui, Katsutoshi Nakayama, Hidetada Sasaki

    研究成果: Article査読

    45 被引用数 (Scopus)


    To determine whether dopamine D1 receptor antagonist impairs the swallowing reflex and reduces substance P (SP) in the peripheral organs, the swallowing reflex in terms of the number of swallows elicited by injections of three different volumes (0.2, 0.4, and 0.6 ml) of distilled water into the pharynx through a catheter was examined in anesthetized guinea pigs pretreated with Sch-23390. Animals were pretreated with either subcutaneous Sch-23390 (200 μg/kg) or a vehicle of Sch-23390 every 12 h for 7 days. The number of swallows was counted by submental electromyographic activity and visual observation of characteristic laryngeal movement. Injections of distilled water caused a volume-dependent increase in the number of swallows in animals without Sch-23390 treatment. Sch-23390 significantly decreased and exogenously administered SP increased the number of swallows elicited by all volumes of distilled water. FK-888 (10-5 M, 1 ml), a specific inhibitor of the NK1 receptor, reduced the number of swallows to a greater degree than Sch-23390. Sch-23390 significantly reduced SP content in the laryngeal and pharyngeal mucosa compared with control. These results suggest that inhibition of the dopamine D1 receptor may impair the swallowing reflex and reduce SP content in the peripheral organs.

    ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    1 43-1
    出版ステータスPublished - 1998 1

    ASJC Scopus subject areas

    • 生理学
    • 生理学(医学)


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