Domino allylation and cyclization of ortho-alkynylbenzaldehydes with allyltrimethylsilane catalyzed by Pd(II)-Cu(II) bimetallic systems

Naoki Asao, Siew Chan Ching, Kumiko Takahashi, Yoshinori Yamamoto

    研究成果: Article査読

    87 被引用数 (Scopus)

    抄録

    The reaction of ortho-alkynylated benzaldehydes 1 with allyltrimethylsilane under the Pd(OAc)2-CuCl2 catalyst system gave the isochromene derivatives 2 together with the chlorinated products 3. When the reaction was conducted in the presence of half equiv of H2O, the formation of 3 was suppressed and 2 was obtained in good to high yields. When the reaction of 1a was carried out with trimethylsilylcyanide instead of allylsilane, the cyano group-substituted isochromene 9 was obtained in 94% yield.

    本文言語English
    ページ(範囲)11322-11326
    ページ数5
    ジャーナルTetrahedron
    61
    48
    DOI
    出版ステータスPublished - 2005 11 28

    ASJC Scopus subject areas

    • 生化学
    • 創薬
    • 有機化学

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