Do the antithrombotic therapy at the time of intracerebral hemorrhage influence clinical outcome? analysis between the difference of antiplatelet and anticoagulant agents and clinical course

Takeshi Okada, Taizen Nakase, Masahiro Sasaki, Tatsuya Ishikawa

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Background It is controversial whether taking antiplatelet agents (APs) or anticoagulant agents (ACs) could influence clinical outcome after intracerebral hemorrhage (ICH). Methods We retrospectively investigated 557 ICH patients between September 2008 and August 2013. We reviewed patients' characteristics, hematoma volume, deterioration (hematoma expansion, surgical hematoma evacuation, or death), and clinical outcome in modified Rankin Scale. Results A total of 397 were classified as neither AP nor AC (Nothing), 81 as single AP (44 as aspirin [ASA], 22 as clopidogrel or ticlopidine [CLP/TIC], 7 as cilostazol, 8 as dual antiplatelet therapy), 43 as single AC (40 as warfarin, 2 as rivaroxaban, 1 as dabigatran), and 36 as both AP and AC (AP + AC). The clinical outcome was worse in APs than in Nothing (P =.021). Among APs, CLP/TIC showed poorer clinical outcome than ASA (P =.020). Deterioration was observed more frequently in AC than in Nothing (P <.001) and the clinical outcome was also worse in AC than in Nothing (P <.001). AP + AC use resulted in deterioration more frequently than Nothing (P <.001) and in poorer outcome than in Nothing (P <.001). Conclusions The use of antithrombotic agents could be associated with the deterioration after admission and the poor clinical outcome. CLP/TIC use may affect the poor outcome compared with ASA use.

本文言語English
ページ(範囲)1781-1788
ページ数8
ジャーナルJournal of Stroke and Cerebrovascular Diseases
23
7
DOI
出版ステータスPublished - 2014 8
外部発表はい

ASJC Scopus subject areas

  • 外科
  • リハビリテーション
  • 臨床神経学
  • 循環器および心血管医学

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