DNA-templated click chemistry for creation of novel DNA binding molecules

Shuhei Imoto, Tomoya Hirohama, Fumi Nagatsugi

研究成果: Article査読

10 被引用数 (Scopus)

抄録

We have developed a new methodology for producing new molecules that bind to dsDNA using DNA-templated click chemistry. The click reactions between the minor groove binding peptide and acridine intercalators were accelerated by the addition of dsDNA. Furthermore, the resulting peptide-acridine conjugate showed a slightly stronger binding to dsDNA. These results indicate that the DNA-templated click chemistry is applicable for screening new binding molecules.

本文言語English
ページ(範囲)5660-5663
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
18
20
DOI
出版ステータスPublished - 2008 10 15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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