DNA recognition control of gamma-PRNA and mismatched base effects upon complex stability.

Hirofumi Sato, Yusuke Hashimoto, Mayuko Kikkawa, Takehiko Wada, Yoshihisa Inoue

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Oligomeric peptide ribonucleic acids (PRNA's), tethering 5'-amino-5'-deoxyribonucleosides as a recognition site for nucleic acids, has been designed and synthesized by solid phase method. PRNA 12-mer found to form stable duplex with complementary DNA.PRNA.DNA duplex composed of PRNA with mismatched DNA has 10-degree lower melting temperature than fullmatched PRNA.DNA duplex. These results demonstrate that binding of PRNA with DNA is sequence specific. It should be emphasized that the on-off switching of PRNA.DNA duplex formation has been realized by the borate added as an external factor.

本文言語English
ページ(範囲)159-160
ページ数2
ジャーナルNucleic acids research. Supplement (2001)
2
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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