Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development

Hideyo Ohuchi, Yasunori Hayashibaral, Hironao Matsuda, Motoyoshi Onoi, Masayuki Mitsumori, Masayuki Tanaka, Junken Aoki, Hiroyuki Arai, Sumihare Noji

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted lysophospholipase D that generates bioactive phospholipids that act on G protein-coupled receptors. Here we show the expression patterns of the ATX gene in mouse and chicken embryos. ATX has a dynamic spatial and temporal expression pattern in both species and the expression domains during neural development are quite distinct from each other. Murine ATX (mATX) is expressed immediately rostral to the midbrain-hindbrain boundary, whereas chicken ATX (cATX) is expressed in the diencephalon and later in the parencephalon- symencephalon boundary. In the neural tube, cATX is expressed in the alar plate in contrast to mATX in the floor plate. ATX is also expressed in the hindbrain and various organ primordia such as face anlagen and skin appendages of the mouse and chicken. These results suggest conserved and non-conserved roles for ATX during neural development and organogenesis in these species.

本文言語English
ページ(範囲)1134-1143
ページ数10
ジャーナルDevelopmental Dynamics
236
4
DOI
出版ステータスPublished - 2007 4

ASJC Scopus subject areas

  • 発生生物学

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