Divergent total synthesis of (-)-aspidophytine and its congeners via Fischer indole synthesis

研究成果: Article査読

26 被引用数 (Scopus)

抄録

A total synthesis of (-)-aspidophytine and the first total syntheses of its congeners, (+)-cimicidine and (+)-cimicine, were accomplished in a divergent manner. Construction of the aspidosperma skeleton was executed by Fischer indole synthesis between substituted phenylhydrazines and tricyclic aminoketone. The regiochemistry of the Fischer indole synthesis was strongly dependent on the choice of acid, and a weak acid, such as acetic acid provided the desired indolenine isomer in high selectivity.

本文言語English
ページ(範囲)89-95
ページ数7
ジャーナルTetrahedron
69
1
DOI
出版ステータスPublished - 2013 1 7

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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