TY - JOUR
T1 - Distribution of carbon-11 labeled methamphetamine and the effect of its chronic administration in mice
AU - Mizugaki, Michinao
AU - Hishinuma, Takanori
AU - Nakamura, Hitoshi
AU - Yamashita, Masamichi
AU - Shimomura, Kohichi
AU - Itoh, Kunihiko
AU - Hirose, Akihiko
AU - Tomioka, Yoshihisa
AU - Aso, Hisashi
AU - Edo, Kiyoto
AU - Takahashi, Toshihiro
AU - Ido, Tatsuo
N1 - Funding Information:
Acknowledgements-This study was performedt hrough a specialc oordinationf und of the Sciencea nd Technology Agencyo f the JapaneseG overnmenat nd was supportedb y a Grant-in-Aid for General ScientificR esearchf rom the Ministry of Education, Science and Culture of Japan (SubjectN o. 02454296).
PY - 1993/5
Y1 - 1993/5
N2 - [11C]Methamphetamine, a psychotropic agent, was synthesized by N-methylation of amphetamine with [11C]CH3I in hopes that it could be applied in the near future to assist positron emission tomography (PET) in the imaging of its distribution in the human brain. The regional distribution of [11C]methamphetamine was investigated in the mice brain at various intervals after an intravenous (i.v.) injection. Radioactivity was higher in the hypothalamus, cortex, striatum and hippocampus. Furthermore, in chronically administered mice, the uptake of [11C]methamphetamine was higher in the striatum than those in other regions. The regional differences in the distribution of methamphetamine in the mice brain may enable the imaging of its distribution by PET using [11C]methamphetamine.
AB - [11C]Methamphetamine, a psychotropic agent, was synthesized by N-methylation of amphetamine with [11C]CH3I in hopes that it could be applied in the near future to assist positron emission tomography (PET) in the imaging of its distribution in the human brain. The regional distribution of [11C]methamphetamine was investigated in the mice brain at various intervals after an intravenous (i.v.) injection. Radioactivity was higher in the hypothalamus, cortex, striatum and hippocampus. Furthermore, in chronically administered mice, the uptake of [11C]methamphetamine was higher in the striatum than those in other regions. The regional differences in the distribution of methamphetamine in the mice brain may enable the imaging of its distribution by PET using [11C]methamphetamine.
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U2 - 10.1016/0969-8051(93)90080-E
DO - 10.1016/0969-8051(93)90080-E
M3 - Article
C2 - 8504290
AN - SCOPUS:0027322767
VL - 20
SP - 487
EP - 492
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 4
ER -
