Dispersion of the neurons expressing layer specific markers in the reeler brain

Hideyuki Dekimoto, Toshio Terashima, Yu Katsuyama

    研究成果: Article査読

    26 被引用数 (Scopus)

    抄録

    Neurons with similar functions including neuronal connectivity and gene expression form discrete condensed structures within the vertebrate brain. This is exemplified within the circuitry formed by the cortical layers and the neuronal nuclei. It is well known that the Reelin protein is required for development of these neuronal structures in rodents and human, but the function of Reelin remains controversial. In this report, we used "layer-specific markers" of the cerebral cortex to carry out detailed observations of spatial distribution of the neuronal subpopulations in the brain of the Reelin deficient mouse, reeler. We observed a spatially dispersed expression of the markers in the reeler cerebral cortex. These markers are expressed also in other laminated and non-laminated structures of brain, in which we observed similar abnormal gene expression. Our observations suggest that neurons within the brain structures (such as the layers and the nuclei), which normally exhibit condensed distribution of marker expressions, loosen their segregation or scatter by a lack of Reelin.

    本文言語English
    ページ(範囲)181-193
    ページ数13
    ジャーナルDevelopment Growth and Differentiation
    52
    2
    DOI
    出版ステータスPublished - 2010 2

    ASJC Scopus subject areas

    • 発生生物学
    • 細胞生物学

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