Discriminative network models of schizophrenia

Guillermo A. Cecchi, Irina Rish, Benjamin Thyreau, Bertrand Thirion, Marion Plaze, Marie Laure Paillere-Martinot, Catherine Martelli, Jean Luc Martinot, Jean Baptiste Poline

研究成果: Conference contribution

32 引用 (Scopus)

抜粋

Schizophrenia is a complex psychiatric disorder that has eluded a characterization in terms of local abnormalities of brain activity, and is hypothesized to affect the collective, "emergent" working of the brain. We propose a novel data-driven approach to capture emergent features using functional brain networks [4] extracted from fMRI data, and demonstrate its advantage over traditional region-of-interest (ROI) and local, task-specific linear activation analyzes. Our results suggest that schizophrenia is indeed associated with disruption of global brain properties related to its functioning as a network, which cannot be explained by alteration of local activation patterns. Moreover, further exploitation of interactions by sparse Markov Random Field classifiers shows clear gain over linear methods, such as Gaussian Naive Bayes and SVM, allowing to reach 86% accuracy (over 50% baseline - random guess), which is quite remarkable given that it is based on a single fMRI experiment using a simple auditory task.

元の言語English
ホスト出版物のタイトルAdvances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference
ページ252-260
ページ数9
出版物ステータスPublished - 2009 12 1
外部発表Yes
イベント23rd Annual Conference on Neural Information Processing Systems, NIPS 2009 - Vancouver, BC, Canada
継続期間: 2009 12 72009 12 10

出版物シリーズ

名前Advances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference

Conference

Conference23rd Annual Conference on Neural Information Processing Systems, NIPS 2009
Canada
Vancouver, BC
期間09/12/709/12/10

ASJC Scopus subject areas

  • Information Systems

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  • これを引用

    Cecchi, G. A., Rish, I., Thyreau, B., Thirion, B., Plaze, M., Paillere-Martinot, M. L., Martelli, C., Martinot, J. L., & Poline, J. B. (2009). Discriminative network models of schizophrenia. : Advances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference (pp. 252-260). (Advances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference).