Discrimination between glucose-1-phosphate and glucose-6-phosphate with a boronic-acid-appended metalloporphyrin

Tomoyuki Imada, Hideomi Kijima, Masayuki Takeuchi, Seiji Shinkai

研究成果: Article査読

23 被引用数 (Scopus)

抄録

When D-glucose-6-phosphate (G-6-P) is bound to boronic-acid-appended zinc(II) porphyrin (2), the δp value in 31P NMR spectroscopy markedly shifts to higher magnetic field and a strong exciton-coupling band appears in CD spectroscopy. Such large changes are not observable for 2 plus D-glucose, 2 plus α-D-glucose-1-phosphate (G-1-P), and for boronic-acid-appended porphyrin (free base: 1) plus these glucose derivatives. This is first example that G-1-P and G-6-P are successfully discriminated by an artificial receptor.

本文言語English
ページ(範囲)2093-2096
ページ数4
ジャーナルTetrahedron Letters
36
12
DOI
出版ステータスPublished - 1995 3月 20
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

フィンガープリント

「Discrimination between glucose-1-phosphate and glucose-6-phosphate with a boronic-acid-appended metalloporphyrin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル