Discovery of new orally active phosphodiesterase (PDE4) inhibitors

Hiroshi Ochiai, Akiharu Ishida, Tazumi Ohtani, Kensuke Kusumi, Katuya Kishikawa, Susumu Yamamoto, Hiroshi Takeda, Takaaki Obata, Hisao Nakai, Masaaki Toda

研究成果: Article査読

14 被引用数 (Scopus)

抄録

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.

本文言語English
ページ(範囲)1098-1104
ページ数7
ジャーナルChemical and Pharmaceutical Bulletin
52
9
DOI
出版ステータスPublished - 2004 9

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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