Direct Carboxylation of Electron-Rich Heteroarenes Promoted by LiO-tBu with CsF and [18]Crown-6

Masanori Shigeno, Kazuya Hanasaka, Keita Sasaki, Kanako Nozawa-Kumada, Yoshinori Kondo

研究成果: Article査読

6 被引用数 (Scopus)

抄録

We herein demonstrate that the combination of LiO-tBu, CsF, and [18]crown-6 efficiently promotes the direct C−H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives). A variety of functional groups, including methyl, methoxy, halo, cyano, amide, and keto moieties, are compatible with this system. The reaction proceeds via the formation of a tert-butyl carbonate species.

本文言語English
ページ(範囲)3235-3239
ページ数5
ジャーナルChemistry - A European Journal
25
13
DOI
出版ステータスPublished - 2019 3 1

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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