Direct C-2 Carboxylation of 3-Substituted Indoles Using a Combined Brønsted Base Consisting of LiO-tBu/CsF/18-crown-6

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Herein, we report that a combination of LiO-tBu, CsF, and 18-crown-6 can be used to carry out the carboxylation of indole derivatives at the C-2 position under an ambient CO2 atmosphere. Substrates bearing an electrophilic substituent (i.e., cyano, formyl, benzoyl, phenylsulfonyl, phenylsulfinyl, and chloride) at the C-3 position are smoothly converted into their corresponding carboxylated products with high functional group compatibility.

本文言語English
ページ(範囲)1987-1991
ページ数5
ジャーナルEuropean Journal of Organic Chemistry
2020
13
DOI
出版ステータスPublished - 2020 4 7

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 有機化学

フィンガープリント

「Direct C-2 Carboxylation of 3-Substituted Indoles Using a Combined Brønsted Base Consisting of LiO-tBu/CsF/18-crown-6」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル