Direct binding between two PDZ domain proteins canoe and ZO-1 and their roles in regulation of the Jun N-terminal kinase pathway in Drosophila morphogenesis

Kuniaki Takahashi, Takashi Matsuo, Takanori Katsube, Ryu Ueda, Daisuke Yamamoto

    研究成果: Article査読

    85 被引用数 (Scopus)

    抄録

    During Drosophila embryogenesis, the ventral epidermis dorsally expands and the left and right epithelial sheets meet and fuse along the dorsal midline. For this dorsal closure to occur, two PDZ domain proteins, Cno and ZO-1, are required. The dorsal epidermis remains open when the expression of ZO-1 and Cno are reduced simultaneously by hypomorphic mutations in the relevant loci. ZO-1 and Cno colocalize at adherens junctions in embryonic epithelia, and form a protein complex upon binding to each other. Genetic analysis showed that Cno is involved in the Jun N-terminal kinase (JNK) pathway for dorsal closure, as a modulator acting upstream of, or in parallel with, the small GTPase Drac1. The ZO-1-Cno complex may be involved in dynamic changes in cytoskeletal organization and cell adhesion during morphogenetic events associated with dorsal closure in the Drosophila embryo.

    本文言語English
    ページ(範囲)97-111
    ページ数15
    ジャーナルMechanisms of Development
    78
    1-2
    DOI
    出版ステータスPublished - 1998

    ASJC Scopus subject areas

    • 胎生学
    • 発生生物学

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