Direct Asymmetric Michael Reaction of α,β-Unsaturated Aldehydes and Ketones Catalyzed by Two Secondary Amine Catalysts

Yujiro Hayashi, Nariyoshi Umekubo

研究成果: Article査読

25 被引用数 (Scopus)

抄録

A direct asymmetric Michael reaction of α,β-unsaturated aldehydes and ketones proceeded in the presence of two pyrrolidine-type catalysts, a diphenylprolinol silyl ether and hydroxyproline, to afford synthetically useful δ-keto aldehydes with excellent diastereo- and enantioselectivity. Although there are several iminium ions and enamines in the reaction mixture, the iminium ion generated by the former catalyst reacts preferentially with the enamine generated by the latter catalyst.

本文言語English
ページ(範囲)1958-1962
ページ数5
ジャーナルAngewandte Chemie - International Edition
57
7
DOI
出版ステータスPublished - 2018 2 12

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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