Differentiating stem cells on patterned substrates for neural network formation

Chunxiong Luo, Li Liu, Xiaofang Ni, Li Wang, Shinichiro M. Nomura, Qi Ouyang, Yong Chen

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Both 3D topographic and 2D adhesive network patterns were used to guide the growth and differentiation of embryonic and mesenchymal stem cells towards a neurogenic lineage. In the case of topographic patterns, lattices composed of square micro-wells for single cell trapping combined with connection channels for neurite outgrowth guidance were designed, with optimal conditions being obtained with large well sizes and short channel lengths. In the case of adhesive micro-contact printed patterns, a similar network design can be applied, but the "well" size should be significantly smaller. Our results also proved the neuron-like characteristics of the induced cellular networks.

本文言語English
ページ(範囲)1707-1710
ページ数4
ジャーナルMicroelectronic Engineering
88
8
DOI
出版ステータスPublished - 2011 8月
外部発表はい

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 凝縮系物理学
  • 表面、皮膜および薄膜
  • 電子工学および電気工学

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