Differential Localization of mRNAs for Mammalian trps, Presumptive Capacitative Calcium Entry Channels, in the Adult Mouse Brain

Yuji Otsuka, Hiroyuki Sakagami, Yuji Owada, Hisatake Kondo

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Mammalian homologues for Drosophila trp are likely to be candidates for capacitative calcium entry channels. By in situ hybridization histochemistry, we have demonstrated that the mRNAs for four species of the mouse homologues (Mtrps-1, -3, -4, -6) were differentially expressed in the adult mouse brain. Mtrp-1 mRNA was expressed widely throughout the gray matters, while the expression for Mtrp-3 was dominant in the cerebellar Purkinje cells, the olfactory mitral cells and the striatal large-sized intrinsic neurons. Mtrp-4 mRNA was evident in the olfactory bulb, the septum, the hippocampal neuronal layers, and the cerebellar granule cell layer, while the expression for Mtry-6 was rather confined to the dentate granule cell layer. Their differential localization suggests that the individual homologues exert their functions in region-specific and neuron-specific manners in the calcium signaling.

本文言語English
ページ(範囲)139-146
ページ数8
ジャーナルTohoku Journal of Experimental Medicine
185
2
DOI
出版ステータスPublished - 1998 6月

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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