Differential diagnosis of lung tumor with positron emission tomography: A prospective study

K. Kubota, T. Matsuzawa, T. Fujiwara, M. Ito, J. Hatazawa, K. Ishiwata, Ren Iwata, T. Ido

研究成果: Article

333 引用 (Scopus)

抜粋

To predict the nature of non-calcifying lung tumors, we performed a prospective study of 46 cases with L-[methyl 11C]methionine (MET, 24 cases) and 18F-fluorodeoxyglucose (FDG, 22 cases) using positron emission tomography (PET). Mean tumor/muscle radioactivity ratios are 5.3 ± 2.0 (n = 14) for malignant and 1.9 ± 0.9 (n = 10) for benign with MET (p < 0.001), and 4.4 ± 2.2 (n = 12) and 1.5 ± 0.3 (n = 10), respectively, with FDG (p < 0.001). The ratios indicate that malignant tumors have higher metabolic demand than benign lesions. Tumors less than 1 cm in diameter were difficult to accurately evaluate due to PET resolution. Compared to the diagnosis at pathology, the MET study showed a sensitivity of 93% (13/14), a specificity of 60% (6/10), and an accuracy of 79% (19/24). The FDG study showed 83% (10/12), 90% (9/10), 86% (19/22), respectively. No significant differences were observed between the two tracers. This study suggests that PET studies using either MET or FDG may be very useful for the differential diagnosis of lung tumors.

元の言語English
ページ(範囲)1927-1932
ページ数6
ジャーナルJournal of Nuclear Medicine
31
発行部数12
出版物ステータスPublished - 1990 12 1

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

フィンガープリント Differential diagnosis of lung tumor with positron emission tomography: A prospective study' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Kubota, K., Matsuzawa, T., Fujiwara, T., Ito, M., Hatazawa, J., Ishiwata, K., Iwata, R., & Ido, T. (1990). Differential diagnosis of lung tumor with positron emission tomography: A prospective study. Journal of Nuclear Medicine, 31(12), 1927-1932.