Differences in bioavailability and tissue accumulation efficiency of (all-E)- and (Z)-carotenoids: A comparative study

Masaki Honda, Soo Takasu, Kiyotaka Nakagawa, Takanori Tsuda

    研究成果: Article査読

    15 被引用数 (Scopus)

    抄録

    This study investigated the differences in bioavailability and tissue accumulation efficiency between all-E- and Z-isomer-rich carotenoids after oral administration to rats. Three commercially important carotenoids (lycopene, β-carotene, and lutein) were chosen for the study. For all carotenoids, feeding with Z-isomer-rich diets increased their concentrations in plasma and tissues at least similar to or more than the all-E-isomer-rich diets, e.g., in rats fed a Z-isomer-rich lycopene, the lycopene concentrations in the plasma and liver after the 2-week administration were respectively 6.2 and 11.6 times higher than those fed an all-E-isomer-rich diet. These results strongly indicate that carotenoid Z-isomers have higher bioavailability and tissue accumulation efficiency than the all-E-isomers. Moreover, diets rich in carotenoid Z-isomers significantly improved the total Z-isomer ratio in plasma and several tissues compared to the all-E-isomers. Since carotenoid Z-isomers potentially have higher antioxidant activity than the all-E-isomers, their accumulation in the body might bring remarkable health benefits.

    本文言語English
    論文番号130119
    ジャーナルFood Chemistry
    361
    DOI
    出版ステータスPublished - 2021 11月 1

    ASJC Scopus subject areas

    • 分析化学
    • 食品科学

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