Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis

Yasuyoshi Kanari, Akiko Sugahara-Tobinai, Haruka Takahashi, Masanori Inui, Akira Nakamura, Sachiko Hirose, Toshiyuki Takai

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Background: The significance of a unique inhibitory Fc receptor for IgG, FcγRIIB (RIIB), in the prevention of spontaneous production of autoantibodies remains controversial, due mainly to the fact that the locus is adjacent to the autoimmune-related locus harboring the genes coding for signaling lymphocyte activation molecules, making it difficult to isolate the effect of RIIB deletion from that of in gene-targeted mice. Our objective was to determine the influence of deletion on the spontaneous development of autoimmune diseases and to compare it with that of potentially pathogenic . Results: We established two congenic C57BL/6 (B6) strains, one with the deletion and the other with , by backcrossing 129/SvJ-based -deficient mice into the B6 genetic background extensively. The RIIB deficiency indeed led to the production and/or accumulation of a small amount of anti-nuclear autoantibodies (ANAs) and to weak IgG immune-complex deposition in glomeruli without any obvious manifestation of lupus nephritis. In contrast, pathogenic in the B6 genetic background induced ANAs but no IgG immune-complex deposition in the kidneys. Naïve mice but not RIIB-deficient mice exhibited hyperplasia of splenic germinal centers. Conclusion: The present results clarify the roles of RIIB in preventing production and/or accumulation of a small amount of ANAs, and development of glomerulonephritis. The combined effects of RIIB deletion and pathogenic SLAM can lead to severe lupus nephritis in the B6 genetic background.

本文言語English
論文番号47
ジャーナルBMC immunology
15
1
DOI
出版ステータスPublished - 2014 10 24

ASJC Scopus subject areas

  • 免疫学

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