Dichotomous control of E/Z-geometry in intramolecular cyclization of o-alkynylbenzamide derivatives catalyzed by organic superbase P4-tBu in the presence/absence of water

Chikashi Kanazawa, Masahiro Terada

研究成果: Article査読

59 被引用数 (Scopus)

抄録

E/Z does it! An intramolecular cycli-zation reaction of o-alkynylbenzamides that allows dichotomous control of E/Z-geometry has been developed using an organic superbase, P4-tBu, as a catalyst. The presence/absence of water along with the use of an organic superbase provides the necessary control of the geometry at the exo-double bond. The method enables efficient access to isoindolinone derivatives, an important class of biologically active molecules.

本文言語English
ページ(範囲)1668-1672+1637
ジャーナルChemistry - An Asian Journal
4
11
DOI
出版ステータスPublished - 2009 11月 2

ASJC Scopus subject areas

  • 生化学
  • 有機化学

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