Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

Hiroyuki Nakamura, Lisa Tasaki, Daisuke Kanoh, Shinichi Sato, Hyun Seung Ban

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Diaryl-substituted ortho-carboranes 1 were synthesized from the corresponding alkynes by decaborane coupling under microwave-irradiated conditions with a combination of N,N-dimethylaniline and chlorobenzene. Among the compounds synthesized, 1a and 1d exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity. Both compounds similarly suppressed hypoxia-induced HIF-1α accumulation in a concentration- dependent manner without affecting HIF-1α mRNA expression.

本文言語English
ページ(範囲)4941-4944
ページ数4
ジャーナルDalton Transactions
43
13
DOI
出版ステータスPublished - 2014 4月 7
外部発表はい

ASJC Scopus subject areas

  • 無機化学

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