Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

Hiroyuki Nakamura; Lisa Tasaki; Daisuke Kanoh; Shinichi Sato; Hyun Seung Ban

doi:10.1039/c3dt52828f

Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

Hiroyuki Nakamura, Lisa Tasaki, Daisuke Kanoh, Shinichi Sato, Hyun Seung Ban

研究成果: Article › 査読

15 被引用数 (Scopus)

抄録

Diaryl-substituted ortho-carboranes 1 were synthesized from the corresponding alkynes by decaborane coupling under microwave-irradiated conditions with a combination of N,N-dimethylaniline and chlorobenzene. Among the compounds synthesized, 1a and 1d exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity. Both compounds similarly suppressed hypoxia-induced HIF-1α accumulation in a concentration- dependent manner without affecting HIF-1α mRNA expression.

本文言語	English
ページ（範囲）	4941-4944
ページ数	4
ジャーナル	Dalton Transactions
巻	43
号	13
DOI	https://doi.org/10.1039/c3dt52828f
出版ステータス	Published - 2014 4月 7
外部発表	はい

ASJC Scopus subject areas

無機化学

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10.1039/c3dt52828f

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Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

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