Diagnosis of autoimmune pancreatitis by EUS-FNA by using a 22-gauge needle based on the International Consensus Diagnostic Criteria

Atsushi Kanno, Kazuyuki Ishida, Shin Hamada, Fumiyoshi Fujishima, Jun Unno, Kiyoshi Kume, Kazuhiro Kikuta, Morihisa Hirota, Atsushi Masamune, Kennichi Satoh, Kenji Notohara, Tooru Shimosegawa

研究成果: Article査読

102 被引用数 (Scopus)

抄録

It is controversial whether EUS-guided FNA by using 22-gauge (G) needles is useful for the diagnosis or evaluation of autoimmune pancreatitis (AIP). To evaluate the usefulness of EUS-FNA by 22-G needles for the histopathological diagnosis of AIP. A retrospective study. Single academic center. A total of 273 patients, including 25 with AIP, underwent EUS-FNA and histological examinations. EUS-FNA by using 22-G needles provided adequate tissue samples for histopathological evaluation because more than 10 high-power fields were available for evaluation in 20 of 25 patients (80%). The mean immunoglobulin G4positive plasma cell count was 13.7/high-power field. Obliterative phlebitis was observed in 10 of 25 patients (40%). In the context of the International Consensus Diagnostic Criteria for AIP, 14 and 6 of 25 patients were judged to have level 1 (positive for 3 or 4 items) and level 2 (positive for 2 items) histological findings, respectively, meaning that 20 of 25 patients were suggested to have lymphoplasmacytic sclerosing pancreatitis based on the International Consensus Diagnostic Criteria. The diagnosis in 1 patient was type 2 AIP because a granulocytic epithelial lesion was identified in this patient. A retrospective study with a small number of patients. The results of this study suggest that EUS-FNA by using 22-G needles provides tissue samples adequate for histopathological evaluation and greatly contributes to the histological diagnosis of AIP.

本文言語English
ページ(範囲)594-602
ページ数9
ジャーナルGastrointestinal Endoscopy
76
3
DOI
出版ステータスPublished - 2012 9

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング
  • 消化器病学

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