Developments toward the production of diverse natural-product-like compounds: Diversity-oriented synthesis and diversity-enhanced extracts

Haruhisa Kikuchi, Yoshiteru Oshima

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Natural products and their derivatives have proven very useful in the search for biologically active compounds and in the development of new drugs because of their structural diversity. However, new approaches that may increase the chemical diversity of such natural products must be developed in order to retain the future usefulness of these compounds. Diversity-oriented synthesis (DOS) has recently emerged as an efficient methodology for constructing complex and diverse compounds from simple and similar precursors. Through the combination of natural product chemistry and DOS, we therefore propose a new approach, diversity-enhanced extracts, for increasing the diversity of natural-product-like compounds. This review describes recent developments toward the production of diverse natural-product-like compounds by DOS based on natural products and direct chemical derivatization of natural extracts, including diversity-enhanced extracts.

本文言語English
ページ(範囲)1509-1527
ページ数19
ジャーナルHeterocycles
96
9
DOI
出版ステータスPublished - 2018

ASJC Scopus subject areas

  • 分析化学
  • 薬理学
  • 有機化学

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