Developmental anatomy of reeler mutant mouse

Yu Katsuyama, Toshio Terashima

    研究成果: Review article査読

    48 被引用数 (Scopus)

    抄録

    The reeler mouse is one of the most famous spontaneously occurring mutants in the research field of neuroscience, and this mutant has been used as a model animal to understand mammalian brain development. The classical observations emphasized that laminar structures of the reeler brain are highly disrupted. Molecular cloning of Reelin, the gene responsible for reeler mutant provided insights into biochemistry of Reelin signal, and some models had been proposed to explain the function of Reelin signal in brain development. However, recent reports of reeler found that non-laminated structures in the central nervous system are also affected by the mutation, making function of Reelin signal more controversial. In this review, we summarized reported morphological and histological abnormalities throughout the central nervous system of the reeler comparing to those of the normal mouse. Based on this overview of the reeler abnormalities, we discuss possible function of Reelin signal in the neuronal migration and other morphological events in mouse development.

    本文言語English
    ページ(範囲)271-286
    ページ数16
    ジャーナルDevelopment Growth and Differentiation
    51
    3
    DOI
    出版ステータスPublished - 2009 4月

    ASJC Scopus subject areas

    • 発生生物学
    • 細胞生物学

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