@article{1223649e02bb4ea28d79923eab000723,
title = "Development of tryptase inhibitors derived from thalidomide",
abstract = "A novel series of tryptase inhibitors with a N-phenylphthalimide skeleton structurally derived from thalidomide (1) has been developed. Structure-activity relationship studies led to a potent and selective tryptase inhibitor, 2-(4-cyanophenyl)isoindole-1,3-dione-5-yl 3-(2-aminopyridin-5-yl)propanoate (7), with the IC 50 value of 78 nM.",
keywords = "Inhibitor, Phthalimide, Serine protease, Thalidomide, Tryptase",
author = "Masashi Tetsuhashi and Minoru Ishikawa and Mariko Hashimoto and Yuichi Hashimoto and Hiroshi Aoyama",
note = "Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan , and the Japan Society for the Promotion of Science .",
year = "2010",
month = jul,
day = "15",
doi = "10.1016/j.bmc.2010.05.037",
language = "English",
volume = "18",
pages = "5323--5338",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "14",
}