TY - JOUR
T1 - Development of the novel drug releasing system triggered by hybridization with target sequence
AU - Nagatsugi, F.
AU - Nakayama, Shizuka
AU - Sasaki, Shigeki
PY - 2007/6
Y1 - 2007/6
N2 - We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to the method for the drug releasing system triggered by hybridization with the target sequence.
AB - We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to the method for the drug releasing system triggered by hybridization with the target sequence.
KW - 2-amino-6-vinylpurine
KW - Cross-link
KW - Drug releasing system
KW - FRET
KW - Oligonucleotides
KW - Synchronous activation
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U2 - 10.1080/15257770701503597
DO - 10.1080/15257770701503597
M3 - Article
C2 - 18066903
AN - SCOPUS:36949012500
SN - 1525-7770
VL - 26
SP - 799
EP - 803
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 6-7
ER -