Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp

Hirotaka Murase, Fumi Nagatsugi

研究成果: Article査読

抄録

RNA higher-order structures play an important role for control of the gene expression, and the small molecules binding to these structures have potential to act as interfering agents in the RNA-mediated-pathway. In this study, we synthesized new RNA binding molecules based on the G-clamp structure and evaluated their binding properties using the model RNA. The monomeric G-clamp ligand exhibited a fluorescence quenching with RNA-binding. The dimeric G-clamp ligand showed a significant fluorescence OFF/ON response to the RNA hairpin structure containing the guanines, indicating a high affinity of the G-clamp dimer to two neighboring guanines located in the RNA hairpin loop.

本文言語English
ページ(範囲)1320-1324
ページ数5
ジャーナルBioorganic and Medicinal Chemistry Letters
29
11
DOI
出版ステータスPublished - 2019 6 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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