Development of [ 18F]FRP-170 injection for imaging hypoxia by PET

Yoichi Ishikawa, Yoshihito Funaki, Ren Iwata, Shozo Furumoto, Eiko Nakata, Yukitsuka Kudo, Tomohiro Kaneta, Takashi Hakamatsuka, Yoshihiro Takai, Shogo Yamada

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A novel [ 18F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ 18F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ 18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.

本文言語English
ページ(範囲)1-10
ページ数10
ジャーナルKakuigaku
42
1
出版ステータスPublished - 2005 4 22

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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