Development of optical and acoustic hybrid microscope for visualization of a single cell

Joe Shikama, Yu Sato, Kazuto Kobayashi, Koki Yoshida, Ryo Nagaoka, Yoshifumi Saijo

研究成果: Article査読

抄録

Acoustic microscope can measure the acoustic parameters of living cells. It is expected that disease mechanism is elucidated, and that treatment methods is developed by analyzing structure and function of cells. In this study, the optical and acoustic hybrid microscope has been developed. The ultrasonic transducer has 250 MHz. As a result of imaging the 3T3-L1 mouse fibroblasts, good contrast was achieved in the portion of the cell nucleus and pseudopod in the acoustic image. In addition, two-dimensional color images of thickness and sound speed of the cell were successfully obtained by using time-resolved analysis. The average thickness was 7.9 μm, and sound speed was 1602 m/s.

本文言語English
ページ(範囲)O-345-O-346
ジャーナルTransactions of Japanese Society for Medical and Biological Engineering
52
DOI
出版ステータスPublished - 2014 8月 17

ASJC Scopus subject areas

  • 生体医工学

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