Development of novel therapies for pulmonary hypertension by clinical application of basic research

Kimio Satoh, Hiroaki Shimokawa

研究成果: Chapter

抄録

Pulmonary hypertension is a lethal disease in which inflammation and oxidative stress are deeply involved in the disease state. We have recently screened novel pathogenic molecules and have performed drug discovery targeting those molecules. To confirm its clinical significance, we used patient-derived blood samples to evaluate the potential as a biomarker for diagnosis and prognosis. Finally, we conducted a high-throughput screening and found inhibitors for the pathogenic proteins. In this chapter, we would like to introduce the recent progress on the basic and clinical research focusing on the screening of pathogenic proteins in pulmonary hypertension.

本文言語English
ホスト出版物のタイトルMolecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
出版社Springer Singapore
ページ125-129
ページ数5
ISBN(電子版)9789811511851
ISBN(印刷版)9789811511844
DOI
出版ステータスPublished - 2020 1 1

ASJC Scopus subject areas

  • Medicine(all)

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