Development of new quantitative diagnosis machine to evaluate the Baroreflex sensitivity of an artery for patients with hypertension

研究成果: Conference contribution

5 被引用数 (Scopus)

抄録

Text book in all medical school showed that the baroreflex system is one of the most important regulatory systems. When blood pressure increases, heart rate decrease and an artery is dilated with the baroreflex system. By decrease of cardiac output and arterial resistances, blood pressure returns to the normal value. However, there is no diagnostic method, which can measure the sensitivity of a baroreflex system of the artery by the simple methodology. We had challenged invention of the new machine, which could diagnose the sensitivity of the baroreflex system of not only a heart, but also an artery. In this system, the measurement sections are only an electrocardiography (ECG) and peripheral pulse wave. These time series is inputted into a personal computer system, and analyzed quantitatively. Responses of the artery were measured with pulse wave velocity (PWV) calculated from pulse wave transmission time from heart to an artery. In this system, the heart rate change corresponding to the blood-pressure change in time series sequence is observed. Delay time was measured by the cross correlation function. Slope of the blood pressure (BP) change and heart rate (HR) change showed the sensitivity of the baroreflex system of heart. Furthermore, this system can measure the sensitivity of the baroreflex system of an artery. Change of PWV in response to the BP change was observed. We found that significant correlation was observed in the time sequence between BP change and PWV change after delay time calculated from cross correlation. Clinical research was started through allowance of the Ethics Committee. Decreased sensibility in the hypertensive patient's baroreflex system was observed as a result of the clinical research. Furthermore, alteration of the baroreflex sensitivity before and after the drug administration was evaluated. For example, Azelnidipine, Calcium antagonists improved the baroreflex sensitivity of the artery in several cases. This system may be useful for the follow up of the hypertensive patients.

本文言語English
ホスト出版物のタイトルProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
ホスト出版物のサブタイトルEngineering the Future of Biomedicine, EMBC 2009
出版社IEEE Computer Society
ページ888-891
ページ数4
ISBN(印刷版)9781424432967
DOI
出版ステータスPublished - 2009 1 1
イベント31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
継続期間: 2009 9 22009 9 6

出版物シリーズ

名前Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
国/地域United States
CityMinneapolis, MN
Period09/9/209/9/6

ASJC Scopus subject areas

  • 細胞生物学
  • 発生生物学
  • 生体医工学
  • 医学(全般)

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