Development of natural product-like compound library for drug discovery based on diversity-enhanced extracts

Haruhisa Kikuchi, Yoshiteru Oshima

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

Natural products and their derivatives have been very useful in the search for biologically active compounds and for the development of new drugs because of their structural diversity. However, to retain their usefulness in the future, new approaches to increase the chemical diversity of such natural products must be developed. Diversity oriented synthesis has recently emerged as an efficient methodology to construct complex and diverse compounds from simple and similar precursors. Thus, through the combination of natural products chemistry and diversity-oriented synthesis, we propose a new approach, diversity-enhanced extracts, for increasing the diversity of natural product-like compounds. Diversity-enhanced extracts are prepared from chemical reactions that remodel molecular scaffolds directly on extracts of natural resources. The subsequent isolation of each compound produced from such reactions affords a diverse natural product-like library. We applied this method of diversification on several medicinal plants. From diversity-enhanced extracts of the medicinal plants, we obtained new and diverse sesquiterpenoids, indole alkaloids, meroterpenoids, and biaryls with some containing new molecular skeletons.

本文言語English
ページ(範囲)349-359
ページ数11
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
75
4
DOI
出版ステータスPublished - 2017

ASJC Scopus subject areas

  • 有機化学

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